中国全科医学2011，Vol.14Issue(33)：3781-3783,3.
尿单核细胞趋化蛋白1和血清胱抑素C在糖尿病肾病早期诊断中的临床意义
Clinical Significance of Urinary Monocyte Chemoattractant Protein-1 and Serum Cystatin C in the Early Diagnosis of Diabetic Nephropathy
柯箫韵 1余育才2
作者信息
- 1. 435003,湖北省黄石市,黄石理工学院医学院
- 2. 黄石理工学院附属医院
- 折叠
摘要
Abstract
Objective To explore the clinical significance of urinary monocyte chemoattractant protein -1 ( UMCP-1 ) and serum cystatin C ( CysC ) in the early diagnosis of diabetic nephropathy. Methods Based on urinary albumin excretion rate ( UAER ), 137 patients with type 2 diabetes were divided into three groups: diabetic nephropathy group ( clinical group,46 cases ), early group of diabetic nephropathy ( early group, 48 cases ), and pre - diabetic nephropathy group ( pre - stage group, 43 cases ) . Fifty healthy subjects were enrolled as controls. UMCP -1 [ in the form of UMCP -1/urinary creatinine ( UMCP - 1/UCr ) ], serum CysC, microalbuminuria ( UMA ) and serum creatinine ( SCr ) concentrations were detected in all groups. Results Levels of UMCP -1 and serum CysC were significantly higher in the pre - stage group than in the control group ( P < 0. 05 ) . Levels of UMCP - 1, serum CysC and UMA were higher in the early group and the clinical group than in the pre -stage group and the control group ( P <0. 01 ) . Relation analysis revealed that both UMCP - 1/UCr and CysC were positively correlated with UMA ( P < 0. 05 ) . Conclusion The combination of urinary UMCP - 1 and serum CysC detection is helpful to the early diagnosis of diabetic nephropathy.关键词
糖尿病肾病/尿单核细胞趋化蛋白1/胱抑素C/尿清蛋白排泄率/尿微量清蛋白/血肌酐Key words
Diabetic nephropathies/ Urinary monocyte chemotactic protein - 1/ Cystatin C/ Urinary albumin excretion rate/ Microalbuminuria/ Creatinine分类
医药卫生引用本文复制引用
柯箫韵,余育才..尿单核细胞趋化蛋白1和血清胱抑素C在糖尿病肾病早期诊断中的临床意义[J].中国全科医学,2011,14(33):3781-3783,3.
