中国全科医学2011，Vol.14Issue(33)：3804-3806,3.
丹红注射液对老年冠心病患者血中对氧磷酶1、超氧化物歧化酶活性及丙二醛水平的影响研究
Impact of Danhong Injection on Paraoxonase 1,Superoxide Dismutase Activity and Malondialdehyde Levels in Aged Patients with Coronary Heart Disease
苏显明 1智晓文 1刘景委 1何亚军 2马奕 1王永兴1
作者信息
- 1. 710061,陕西省西安市,西安交通大学医学院第一附属医院老年心血管内科
- 2. 陕西省核工业215医院心内科
- 折叠
摘要
Abstract
Objective To explore the possible mechanism of Danhong injection on the treatment of elderly patients with coronary heart disease ( CHD ). Methods Totally 98 elderly CHD patients diagnosed by coronary angiography were randomly divided as conventional treatment group ( n = 48 ) and Danhong injection treatment group ( n = 50 ), then the serum paraox-onase 1 ( PON 1 ) activity before and after the treatment in the two groups was measured by using pheny acetate method, and su-peroxide dismutase ( SOD ) activity and malondialdehyde ( MDA ) content were measured by using colorimetric method. Results PON1 and SOD activities of elderly CHD patients were significantly lower than those of elderly non - CHD patients; and MDA level of elderly CHD patients was significantly higher than that of elderly non - CHD patients ( P < 0. 05 ). The PON1 and SOD activities were significantly increased and MDA level was significantly reduced after 4 - week Danhong injection treatment ( P < 0. 05 ). There was different degrees of change in levels of PON1, SOD and MDA after 4 - week conventional treatment, but with no significant difference ( P > 0. 05 ). There were significant difference in PON1 and SOD activities, and MDA level after 4 -week treatment between Danhong injection group and conventional treatment group ( P <0. 05 ). Conclusion There is the phenomenon of lipid peroxidation in the elderly CHD patients. Danhong injection can raise serum PON1 and SOD activities, and lower MDA level to improve the antioxidant capability of elderly CHD patients.关键词
冠状动脉疾病/老年人/对氧磷酶1/丙二醛/超氧化物歧化酶Key words
Coronary artery disease/ Aged/ Paraoxonasel/ Malondialdehyde/ Superoxide dismutase分类
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苏显明,智晓文,刘景委,何亚军,马奕,王永兴..丹红注射液对老年冠心病患者血中对氧磷酶1、超氧化物歧化酶活性及丙二醛水平的影响研究[J].中国全科医学,2011,14(33):3804-3806,3.
