重庆医学2011，Vol.40Issue(32)：3270-3271,3273,3.DOI:10.3969/j.issn.1671-8348.2011.32.022
微柱凝集技术对O型血孕妇IgG抗体效价的检测及意义
Significant of titration of IgG antibody against "O" blood goup in pregnant women by using microcolumn gel coombs′ test
摘要
Abstract
Objective To analysis of IgG anti-A and anti-B titre in serum of pregnant women with blood type O. Methods 224 blood samples of pregnant women with blood type O, whose husbands were of blood type A or B, were detected by microcolumn gel Coombs' test. Results 85(37. 9%) cases abnormity of IgG antibody titre in 224 pregnant women with blood type () 34(36. 2%) abnormity of 94 pregnant women in O-A blood type couple group, 27 (29. 7%) abnormity in O-B blood type couple group, 24 (61. 5%) abnormity of anti-A titre and 15(38. 5%) abnormity of anti-B titre in 39 pregnant women in O-AB blood type couple group. Detection of IgG anti-A and anti-B titre in serum of pregnant women in 22 cases O-A couple group,21 cases O-B couple and 14 cases O-AB couple group were dynamic analysis. The result shows birth a neonate without hemolytic disease of the newborn (HDN) in 54 cases IgG titre(anti-A or anti B) ≥ : 64 in serum of pregnant women in the first instance without continued increase of IgG titre and a neonate with HDN in anti A titre 1 : 512 and anti-B tire 1 : 256 in the first with continued increase to 1 : 1 024 titre of both anti-A and anti-B IgG titre. Conclusion Detecting titre of blood type antibody IgG in serum of pregnant women with ABO alloimmunization is helpful to diagnose HDN and to instruct, interventions to lower incidence of the disease. Specially,dynamic analysis should be done for pregnant women with high IgG titre of anti-A and/or anti-B.关键词
免疫球蛋白G/微柱凝胶技术/O型血孕妇Key words
immunoglobulin G/microcolumn gel coombs' test/o blood type pregnant women引用本文复制引用
刘玲,陈亚宝,叶军,孙雅馨,顾生贵,戴跃仙,叶勇..微柱凝集技术对O型血孕妇IgG抗体效价的检测及意义[J].重庆医学,2011,40(32):3270-3271,3273,3.基金项目
泰州市科学技术局科技发展计划资助项目(TS0904). （TS0904）
