重庆医学2011，Vol.40Issue(32)：3276-3277,3279,封3,4.DOI:10.3969/j.issn.1671-8348.2011.32.025
PRDX1在结直肠癌中的表达及其临床意义
The expression of PRDX1 in colorectal cancer and its clinical significance
蒋尧 1傅仲学 2吴星烨2
作者信息
- 1. 重庆市渝州监狱医院,400026
- 2. 重庆医科大学附属第一医院外三科,400016
- 折叠
摘要
Abstract
Objective To investigate the expression of peroxiredoxin 1(PRDX1) and its clinical significance in histological samples of colorectal neoplasm and the distant normal tissues. Methods In 32 cases of colorectal cancer, the expression of PRDX1 in histological samples of colorectal neoplasm and the distant normal tissues was detected by immunohistochemistry. A total of 8 tumor specimens and a corresponding nonmalignant sample of colorectal from distant areas of the same patient were selected for western bolt analysis,and the correlations with patient clinical and pathological data such as sex,age,stage and lymphnodes metastasis were analyzed. Results Immunohistochemistry indicated that PRDX1 protein was expressed mainly in the cytoplasm. In distant normal colorectal tissues(15. 63% ,5/32) showed weak expression of PRDX1 compared with it in carcinomas tissue(65. 63% , 21/32) ,the differences had statistical significance(P<0.01). In line with the immunohistochemistry, western blot analysis revealed PRDX1 protein was significantly higher in carcinomas than in control colorectal tissues. When comparing PRDX1 with clinicopatho-logical parameter,it did not have significant association with sex or age(P>0.05). However,PRDX1 showed significantly increased expression in colorectal cancer patients with stage III or lymphnodes metastasis-positive cases(P<0.05). Conclusion In colorectal tumors,the expression of PRDX1 is higher; it might be involved in tumor progression and played a role in diagnosis and treatment of colorectal cancer.关键词
结直肠肿瘤/活性氧/过氧化氧化还原蛋白1Key words
colorectal neoplasms/ reactive oxygen species/ peroxiredoxin 1引用本文复制引用
蒋尧,傅仲学,吴星烨..PRDX1在结直肠癌中的表达及其临床意义[J].重庆医学,2011,40(32):3276-3277,3279,封3,4.
