中国神经再生研究（英文版）2011，Vol.6Issue(32)：2485-2489,5.DOI:10.3969/j.issn.1673-5374.2011.32.001
Brain-derived neurotrophic factor protects PC12 cells from beta-amyloid-induced neurotoxicity through the tropomyosin-related kinase B receptor pathway
Brain-derived neurotrophic factor protects PC12 cells from beta-amyloid-induced neurotoxicity through the tropomyosin-related kinase B receptor pathway
Zhikun Sun 1Xingrong Ma 2Hongqi Yang 1Jiahua Zhao 1Jiewen Zhang1
作者信息
- 1. Department of Neurology,Henan Provincial People's Hospital,Zhengzhou 450002,Henan Province,China
- 2. Department of Neurology,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China
- 折叠
摘要
Abstract
The present study utilized beta amyloid (Aβ)-induced cell apoptosis in PC12 cells as a cell model of Alzheimer's disease to investigate the interaction between brain-derived neurotrophic factor (BDNF) and the tropomyosin-related kinase B receptor.Results showed that Aβ(25-35) can reduce survival of PC12 cells and increase cleaved caspase-3 expression in PC12 cells.However, BDNF inhibited Aβ(25-35)-induced cytotoxicity and cleaved casapase-3 expression.Interestingly, pretreatment with the tropomyosin-related kinase receptor inhibitor K252a for 20 minutes prior to BDNF blocked the neuroprotective effect of BDNF on PC12 cells.关键词
β-amyloid/apoptosis/brain-derived neurotrophic factor/Alzheimer's disease/caspase-3/tropomyosin-related kinase BKey words
β-amyloid/apoptosis/brain-derived neurotrophic factor/Alzheimer's disease/caspase-3/tropomyosin-related kinase B引用本文复制引用
Zhikun Sun,Xingrong Ma,Hongqi Yang,Jiahua Zhao,Jiewen Zhang..Brain-derived neurotrophic factor protects PC12 cells from beta-amyloid-induced neurotoxicity through the tropomyosin-related kinase B receptor pathway[J].中国神经再生研究（英文版）,2011,6(32):2485-2489,5.
