中国神经再生研究（英文版）2011，Vol.6Issue(32)：2495-2499,5.DOI:10.3969/j.issn.1673-5374.2011.32.003
Increased expression of aquaporin-4 in brain tissue of amygdala-kindled rats
Increased expression of aquaporin-4 in brain tissue of amygdala-kindled rats
摘要
Abstract
Recurrent epileptic seizures can lead to brain edema, indicating that water regulation may be perturbed by seizures.We hypothesized that the expression of the brain water channel aquaporin-4 (AQP-4) may be upregulated in the epileptic brain.In the present study, we established the amygdala kindling model of epilepsy, and quantified AQP-4 protein and mRNA levels, using reverse transcription-PCR, immunohistochemistry and western blotting, in epileptic and control rats.We found that AQP-4 was overexpressed in the cerebral cortex of rats with epilepsy compared with controls.These findings show that AQP-4 is highly expressed in the brain of amygdala-kindled rats, suggesting that repeated seizures affect water homeostasis in the brain.关键词
epilepsy/aquaporin-4/brain edema/amygdala/neural regenerationKey words
epilepsy/aquaporin-4/brain edema/amygdala/neural regeneration引用本文复制引用
Yinghui Chen,Yongbo Zhao..Increased expression of aquaporin-4 in brain tissue of amygdala-kindled rats[J].中国神经再生研究（英文版）,2011,6(32):2495-2499,5.基金项目
the Natural Science Foundation of Shanghai,No.09ZR1405500 （）
the Research Projects of Shanghai Municipal Health Bureau,No.2008-08 （）
