中国全科医学2011，Vol.14Issue(33)：3793-3795,3.
吡咯列酮与胰岛素联用对2型糖尿病患者β细胞早期胰岛素分泌的影响
Impact of Pioglitazone Combined with Insulin on Early Phase Insulin Secretion of β-Cells Function in Type 2 Diabetic Patients
摘要
Abstract
Objective To study the protective effect of Pioglitazone combined with insulin on period insulin secretion of p - cell function in patients with type 2 diabetes mellitu. Methods Forty patients with type 2 diabetes mellitu were randomly divided into two groups, Pioglitazone combined with insulin group and insulin group. On the basic dietary and exercise therapies, the course of treatment was 12weeks. fasting blood glucose ( FBG ), 2 -hour postprandial blood glucose ( 2 hPBG ), fasting serum insulin ( FINS ), glycosylated hemoglobin ( HbA,c ), area under curve of C peptide 0 ~ 30 min after glucose load ( AUCcpO ~ 30 ), HOMA index of p - cell function ( HOMA - p ) and HOMA insulin resistance index ( HO MA - IR ) were compared between the two groups. Results After 12-week treatment, FBG, 2 hPBG, HbA1c and HOMA -IR were significantly increased in both group; while FINS, AUCcpO ~ 30, and HOMA - β were significantly decreased ( P < 0. 05 ) . The improvement was more significant in Pioglitazone combined with insulin group than in insulin group. Conclusion The therapy of Pioglitazone combined with insulin can effectively improve the early phase insulin secretion of p - cell, being helpful to long term control of blood glucose.关键词
糖尿病,2型/吡咯列酮/早相胰岛素分泌Key words
Diabetes mellitus, type 2/ Pioglitazone/ Early phase insulin secretion分类
医药卫生引用本文复制引用
黄宇清,刘蓉,罗红娥,曾菊丽,刘居庄..吡咯列酮与胰岛素联用对2型糖尿病患者β细胞早期胰岛素分泌的影响[J].中国全科医学,2011,14(33):3793-3795,3.基金项目
江西省教育厅2011年度科技项目(GJJ11182) （GJJ11182）
吉安市科技局2010年度指导性科技计划项目(科计字[2010]18号) （科计字[2010]18号）
