中国康复理论与实践2011，Vol.17Issue(9)：834-836,3.
地塞米松对内毒素休克大鼠脑组织细胞因子含量的影响
Effect of Dexamethasone on Cytokine in Brain of Rats with Endotoxin Shock
摘要
Abstract
Objective To explore the effect of the dexamethasone on the levels of cytokine in the brain of endotoxin shock rats. Methods 54 Sprague-Dawley rats were randomized to the sham group, LPS group (lipopolysaccharide 8 mg/kg, I.v.) and DEX group (dexamethasone 5 mg/kg, I.v., in addition). The blood pressure was measured dynamically. The contents of interleukin (IL)-4, IL-10 and tumor necrosis factor (TNF)-a were detected with ELISA 1 h, 3 h, 6 h after shock. Results As the occurrence and development of shock, blood pressure went down gradually, IL-4 and IL-10 decreased (P<0.01), and TNF-α increased (P<0.01) in LPS group, while the TNF-α decreased (P< 0.01), the IL-4 and IL-10 increased (P<0.01) in the DEX group compared with the LPS group. Conclusion Dexamethasone may protect the brain from the endotoxin shock injury in rats through regulating the inflammatory factor.关键词
内毒素休克/脑损伤/地塞米松/细胞因子/大鼠Key words
endotoxin shock/ brain injury/ dexamethasone/ cytokine/ rats分类
医药卫生引用本文复制引用
王新芳,张宇忠,任丽薇,贾旭,庞丹丹..地塞米松对内毒素休克大鼠脑组织细胞因子含量的影响[J].中国康复理论与实践,2011,17(9):834-836,3.基金项目
国家自然科学基金项目(30672737). （30672737）
