摘要
Abstract
Objective: To study the efficacy and side effects of combined pirarubicin (THP), etoposide, and cytarabine (TEA regimen) in the treatment of relapsed/refractory acute myeloid leukemia. Methods:A course of treatment included 20mg/d of THP with intravenous infusion for 3 d, 100mg/d of etoposide with intravenous infusion for 3d, and l00mg/d of cytarabine with intravenous infusion for 5~7 d. Fifteen eligible patients diagnosed as relapsed/refractory acute myeloid leukemia were enrolled and received the TEA regimen in this study. Results:Five cases achieved complete remission (CR), with a CR rate of 33. 3%, while 3 cases reached partial remission (PR), with a PR rate of 20%, resulting in a total efficacy rate of 53. 3%. Five patients ended up with non-remission (NR) while 2 cases were discharged earlier and could not be followed-up. Side effects included bone marrow suppression, fever, gastrointestinal disorders and mild liver injury. Conclusion: TEA regimen in the treatment of relapsed/refractory acute myeloid leukemia is effective, showed mild side effects, and should be widely promoted.关键词
白血病,髓样,急性/药物疗法/蒽环类/治疗应用/阿糖胞苷/治疗应用Key words
Leukemia, myeloid, acute/drug therapy/Anthracyclines/therapeutic use/Cytarabine/ therapeutic use分类
医药卫生
