中国临床药理学杂志2011，Vol.27Issue(10)：762-766,5.
细胞色素P450(CYP)3A5与CYP2C19基因多态性对伏立康唑在健康人体的药代动力学特征的影响
Effect of cytochrome P450(CYP)3A5, CYP2C19 gene polymorphism on pharmacokinetic characteristics of voriconazole in Chinese healthy volunteers
摘要
Abstract
Objective To study the effect of cytochrome P450(CYP) 3A5, CYP2C19 gene polymorphism in Chinese healthy human on the pharmacokinetics of voriconazole. Methods Genotyping of CYP3A5 and CYP2C19 was made with the method of RFLP - PCR targeted in healthy volunteers' blood. An LC - MS method for the determination of voriconazole in plasma was established. After a single oral dose 200 mg voriconazole tablets, the concentration of voriconazole plasma was determinatied using the above LC - MS method. Results The main pharmacokinetic parameters of AUC0-36 AUC0-∞ of CYP2C19 homozygous was notable higher than wild type and the heterozygous. The parameter of CL/F was notable lower than the wild type at dose of 200 mg. But the parameters of T1/2, Cmax had no statistical differences. CYP3A5 gene polymorphism had no statistical differences on pharmacokinetic parameters of voriconazole. Conclusion CYP2C19 gene polymorphism do affect the pharmacokinetic parameters of voriconazole and CYP3A5 gene polymorphism do not affect the pharmacokinetic parameters of voriconazole.关键词
细胞色素P4503A5/细胞色素P4502C19/基因多态性/伏立康唑/药代动力学Key words
cytochrome P4503A5 polymorphism/ cytochrome P4502C19 polymorphism/ voriconazole/ pharmacokinetics分类
医药卫生引用本文复制引用
黄菲,夏春华,熊玉卿..细胞色素P450(CYP)3A5与CYP2C19基因多态性对伏立康唑在健康人体的药代动力学特征的影响[J].中国临床药理学杂志,2011,27(10):762-766,5.基金项目
国家十一五科技重大专项基金资助项目(2009ZX09309-003-02) （2009ZX09309-003-02）
国家十二五科技重大专项基金资助项目(2011ZX09302-007-03) （2011ZX09302-007-03）
