中药材Issue(8)：1225-1229,5.
鲜香附挥发油镇痛活性及其GC-MS分析
GC-MS Analysis and Analgesic Activity of Essential Oil from Fresh Rhizoma of Cyperus rotundus
摘要
Abstract
Objective;To observe the analgesic effect and analysis the chemical components of essential oil ( EOC) from fresh rhizome of Cyperus rotundus. Methods: Hydrodistillation method was used to extract EOC; Acetic acid induced mice stretching model was applied to evaluate the analgesic, effect of EOC. Gas chromatography coupled with mass spectrometry (GC-MS) were applied for the a-nalysis of EOC. Results;The yield of EOC was 0. 4%. The stretching times of mice induced by acetic acid were significantly reduced by EOC at dosage of 0. 1 g/kg. 54 ingredients, 85.1% of which were EOC were identified by GC-MS analysis; The major compounds were cyperene(41. 03 % ), B-caryophyllene oxide(5. 32% ) , a-selinene(4. 37% ), a-copaene(4. 36% ) .naphthalene, 6-isoproenyl-4,8a-dimethyl-l ,2,3,5,6,7,8,8a-octahydro-(3. 80% )and a-cyperone(3. 11% ). Conclusion; The essential oil from fresh rhizome of Cyperus rotundus shows structure diversity and good analgesic effect.关键词
鲜香附/挥发油/镇痛/GC-MSKey words
Fresh rhizome of Cyperus rotundus/ Essential oil/ Analgesic activity/ GC-MS analysis分类
医药卫生引用本文复制引用
陈运,赵韵宇,王晓轶,刘金涛,黄立群,彭崇胜..鲜香附挥发油镇痛活性及其GC-MS分析[J].中药材,2011,(8):1225-1229,5.基金项目
上海交通大学“第三期国家大学生创新性实验计划”(091024848) （091024848）
综合性新药研究开发技术大平台(2009ZX09302-007) （2009ZX09302-007）
