中药材2011，Vol.34Issue(9)：1388-1391,4.
黄芪丹参药对及其有效组分对UUO大鼠肾组织JAK/STAT信号通路的影响
Effect of Astragalus and Salvia's Effective Components and Their Compatibility on JAK/STAT Pathway
摘要
Abstract
Objective:To study the effect of Astragalus and Salvia's effective components and their compatibility on JAK/STATpathway of rats' renal fibrosis. Methods:66 SD rats were randomly divided into 7 groups:normal group,model group, fosinopril group, salvianolic acids group,astragalus saponins group,granules compatibility of Astragalus and Salvia group,components combination of Astragalus and Salvia group. The variation of ￡2-microglobulin(￡2-MG) ,the changes of renal pathology and JAK/STAT pathway were observed. Results;The changes in renal pathology of treatment groups had different degrees of improvement; Astragalus and Salvia could reduce the urinary ;82-MG of unilateral ureteral obstruction (UUO) rat (P <0. 05) .which was equal with fosinopril group. The rest of the treatment groups decreased especially fosinopril group while the difference was not significant when compared with the model group. Astragalus and its effective components could reduce the expression of renal tissue JAK.STAT1 ,STAT3 protein, among which fosinopril group and granules compatibility of Astragalus decreased significantly. Astragalus saponins group was not obvious, and the rest of the treatment group had significantly minor effect Conclusion: Astragalus and Salvia's effective components and their compatibility may protect renal tubular function in unilateral ureteral obstruction, which may interfere with UUO rat kidney with JAK/STAT signaling pathway.关键词
肾纤维化/JAK/STAT信号通路/黄芪丹参药对/丹参总酚酸/黄芪总皂苷Key words
Renal fibrosis/JAK / STAT fosinopril/Compatibility of Astragalus and Salvia Salvianolic acids/Astragalus saponins分类
医药卫生引用本文复制引用
李均,曹轶璇,王冬,周萍,阳小敏..黄芪丹参药对及其有效组分对UUO大鼠肾组织JAK/STAT信号通路的影响[J].中药材,2011,34(9):1388-1391,4.基金项目
国家自然基金(30960490) （30960490）
贵州省社会攻关项目(黔科合SY字[2009]3078) （黔科合SY字[2009]3078）
贵州省省长基金项目黔省专合字[(2010)69] （2010）
