中药材2011，Vol.34Issue(9)：1403-1405,3.
冬虫夏草子实体对小鼠学习记忆的影响
Effect of Cordyceps sinensis Sporocarp on Learning-memory in Mice
摘要
Abstract
Objective;To study the effect of extracts of Cordyceps sinensis sporocarp on learning-memory in scopolamine treated mice and the possible mechanism. Methods;ICR mice were randomly divided into five groups;sham control,model,piracetam and CSE 0. 5,1 g/kg. Lotomotor activity was assessed. Morris water maze was used to evaluate the memory ability of mice 30min later after ip scopolamine 1.0 mg/kg BW. Then acitivity of AchE was measured after behavioral test. Results;CSE had no influence on lotomotor activity. However,CSE 0.5,1 g/kg both shortened escape latency and increased times of come-crossing platform in Morris water maze, meanwhile activity of AchE in the brain was decreased by CSE. Conclusion: CSE can significantly improve the learning and memory impairment in mice induced by scopolamine, which may be correlated with the inhibition of activity of AchE.关键词
冬虫夏草子实体/东莨菪碱/学习记忆/Morris水迷宫Key words
Cordyceps sinensis sporocarp/Scopolamine/Learning-memory/Morris water maze分类
医药卫生引用本文复制引用
拱梅芳,徐江平,储智勇,栾洁..冬虫夏草子实体对小鼠学习记忆的影响[J].中药材,2011,34(9):1403-1405,3.基金项目
粤港关键领域重点突破项目(粤科规划字[2009]209号) （粤科规划字[2009]209号）
