中国药理学通报2011，Vol.27Issue(12)：1653-1655,3.DOI:10.3969/j.issn.1001-1978.2011.12.007
苯佐卡因对大鼠背根神经节神经元河豚毒素不敏感型钠离子通道的影响
Effects of benzocaine on tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons
摘要
Abstract
Aim To investigate the effects of benzo-caine ( BZC ) on tetrodotoxin-resistant ( TTX-r ) Na+ currents in the rat dorsal root ganglion ( DRG ) neurons. Methods Neonatal rat DRG cells were isolated and the effects of BZC on TTX-r Na + currents were observed by whole cell patch clamp recordings. Results BZC tonically blocked the TTX-r Na+ currents con-centration-dependently, and the percentages of block by 30, 100 and 300 μnol. L-1 BZC on TTX-r Na + currents were ( 18. 83 ± 8.51 )% , ( 33.08 ± 9. 19 )% and ( 58. 91 ± 12. 02 )% respectively. Inaddition, BZC shifted the steady-state inactivation curves of TTX-r Na+ currents to the hyperpolarization direction, also in a concentration-dependent manner. Conclusion BZC may induce analgesic effect by inhibiting TTX-r Na + currents of DRG neurons and shifting steady-state inactivation curves to more negative potential values.关键词
苯佐卡因/背根神经节神经元/全细胞膜片钳技术/钠电流.静息阻断.稳态失活曲线Key words
benzocaine/ dorsal root ganglion neurons/ whole cell patch clamp/ Na+ currents/ tonic block/ steady-state inactivation curves分类
医药卫生引用本文复制引用
章艳,陈少锐,贾岩岩,刘培庆,蒋建敏..苯佐卡因对大鼠背根神经节神经元河豚毒素不敏感型钠离子通道的影响[J].中国药理学通报,2011,27(12):1653-1655,3.基金项目
国家自然科学基金资助项目(No 30811120434) （No 30811120434）
