感染、炎症、修复2011，Vol.12Issue(3)：172-174,3.
乌司他丁对主动脉夹层术后急性肺损伤治疗效果的研究
Effects of Ulinastatin on acute lung injury after operation for dissecting aneurysm of aorta
章淬 1穆心苇 1牛永胜 1陈永铭 1程子昊1
作者信息
- 1. 南京医科大学附属南京第一医院重症医学科,江苏,南京,210006
- 折叠
摘要
Abstract
Objective:To study the therapeutic effect of Ulinastatin on acute lung injury (ALI) after the surgery treatment of aortic dissecting aneurysm. Methods :Thirty-nine patients with ALI after the surgical treatment of aortic dissecting aneurysm were enrolled in the study. Eighteen patients who were admitted in 2009 (control group) were treated with conventional therapy only, 21 patients who were admitted in 2010 (Ulinastatin group) were treated with conventional therapy and Ulinastatin 300 kU+100 ml normal saline for injection once a day for 3 days. The changes in oxygenation index (PaO2/FiO2), respiratory index (Pa-2 O2/PaO2), length of mechanical ventilation, length of stay in ICU, and in-hospital mortality were compared between the two groups. Results: PaO2/FiO2 increased while PA-2O2/PaO2 dropped significantly in the Ulinastatin treatment group on the second and the third days compared to that of the first day after the operation. There was no significant difference in length of mechanical ventilation, length of ICU stay and in-hospital mortality between the two groups. Conclusions: Ulinastatin has therapeutical effect on acute lung injury after operation for dissection aneurysm of aorta by depressing the acute inflammatory response.关键词
主动脉夹层/肺损伤,急性/乌司他丁Key words
Aortic dissecting aneurysm / Acute lung injury/ Ulinastatin引用本文复制引用
章淬,穆心苇,牛永胜,陈永铭,程子昊..乌司他丁对主动脉夹层术后急性肺损伤治疗效果的研究[J].感染、炎症、修复,2011,12(3):172-174,3.
