解放军医学杂志2011，Vol.36Issue(10)：1053-1056,4.
三聚氰胺氰尿酸盐致肾脏损害的实验研究
An experimental study on renal damage induced by melamine cyanurate
于管天 1廖松柏 2于永刚 2武英杰 2刘为池 2廖桂祥 2刘刚2
作者信息
- 1. 510515 广州 南方医科大学研究生院
- 2. 541002 广西桂林 解放军181医院泌尿外科
- 折叠
摘要
Abstract
Objective To explore the nephrotoxicity of melamine cyanurate in SD rats. Methods Ninety SPF SD rats were randomly assigned into 3 groups (30 each) according to the doses of melamine cyanurate they received (0, 200, 400mg/kg), which were repectively given daily by gavage for 60 consecutive days. Six rats in each group were confined in metabolism cages for the first week, and urine samples were collected over a 24h period. Before drug administration, the blood samples and kidney pathology were evaluated in 6 rats of each group on day 4, 14, 31, 45 and 60 to determine serum creatinine, blood urea nitrogen (BUN), serum uric acid and serum cystatin C. Results The urine volume of rats was significantly higher in 200mg/kg group than in normal controls ( P<0.05), while no statistical difference was found between 400mg/kg and control group. After administration of melamine cyanurate, the levels that of serum cystatin C increased significantly, while that of serum uric acid decreased markedly, as compared with the control group (P<0.05). Sgnificantly higher levels of BUN, serum cystatin C and creatinine were found in 200 mg/kg group (30-60 days) and 400mg/kg group (4th day) compared with that of control group (P<0.01). On the 2nd day, specific crystals were found in the urinary sediment smears of melamine cyanurate group. The pathological changes in kidney included yellow discoloration and edema of the organ in 200mg/kg group (since 31st day) and 400mg/kg group (since 4th day). Examination of pathological sections showed that there was deposition of a number of yellow, semi-transparent and concentric round crystals in renal tubules. Conclusions Administration of melamine cyanurate by gavage may induce crystal formation and cause renal dysfunction. Meanwhile, melamine cyanurate may have some diuretic function, thereby influence the metabolism and decrease the concentration of uric acid in blood.关键词
三聚氰胺氰尿酸盐/肾功能衰竭/肾结石/尿酸Key words
melamine cyanurate/ kidney failures kidney calculi/ uric acid分类
医药卫生引用本文复制引用
于管天,廖松柏,于永刚,武英杰,刘为池,廖桂祥,刘刚..三聚氰胺氰尿酸盐致肾脏损害的实验研究[J].解放军医学杂志,2011,36(10):1053-1056,4.
