解放军医学杂志2011，Vol.36Issue(10)：1071-1073,3.
血清新喋呤水平对活动性肺结核的诊断价值研究
Significance of sermn neopterin level in diagnosis of active pulmonary tuberculosis
石学萍 1齐曼古力·吾守尔 2王泉 3接力4
作者信息
- 1. 新疆维吾尔自治区胸科医院
- 2. 830054 乌鲁木齐 新疆医科大学第一附属医院呼吸一科
- 3. 830049 乌鲁木齐 新疆维吾尔自治区胸科医院检验科
- 4. 830049 乌鲁木齐 新疆维吾尔自治区胸科医院结核二科
- 折叠
摘要
Abstract
Objective To investigate the sensitivity and specificity of serum neopterin (Np) level in diagnosis of active pulmonary tuberculosis. Methods Patients with pulmonary tuberculosis, admitted to Xinjiang Chest Hospital from Apr. 2009 to May 2010, were consecutively enrolled in present study. Serum neopterin level was determined with enzyme linked immunosorbent assay (ELISA) in the next morning of admission. VCG purified protein derivative test (PPD) was concurrently performed. Results Fifty-eight cases with active (group A) and 18 with stable (group S) pulmonary tuberculosis were recruited, and 32 healthy volunteers served as control (group C). The mean Np level was significantly higher in group A (54.14 ±19. 85 nmol/L) than in group S (29. 51 ±8.23 nmol/L) and group C (20. 67±9. 68 nmol/L, P<0.01). No statistical difference was found between group S and group C ( P>0.05). Among patients with active pulmonary tuberculosis, the mean Np level increased significantly in cases with the fibro-cavitative pulmonary tuberculosis (77.43± 22.13), compared with those cases with invasive (46.07 ± 13.04) and hematogenous disseminated pulmonary tuberculosis (48.48± 8. 34 nmol/L, P<0.01), while no statistical difference existed between the latter two. The receiver operating characteristic (ROC) curve showed that the area under curve (AUC) was 0. 951 in the cutoff value of 36.73 nmol/L, and the sensitivity and specificity were 86% and 92% for predicting active pulmonary tuberculosis, and it was significantly higher than PPD test (P<0.01), in which the sensitivity was 52% and specificity was 78%. Conclusions Np level may serve as one of the important adjunctive parameters for early diagnosis of active pulmonary tuberculosis due to its high sensitivity and specificity.关键词
结核,肺/酶联免疫吸附测定/敏感性与特异性Key words
tuberculosis, pulmonary/ enzyme-linked immunosorbent assayi sensitivity and specificity分类
医药卫生引用本文复制引用
石学萍,齐曼古力·吾守尔,王泉,接力..血清新喋呤水平对活动性肺结核的诊断价值研究[J].解放军医学杂志,2011,36(10):1071-1073,3.
