青岛大学医学院学报2011，Vol.47Issue(6)：498-500,3.
铬中毒致大鼠听力损伤及铜与锰对其的拮抗作用
HEARING IMPAIRMENT IN RATS CAUSED BY CHROMIUM AND THE ANTAGONISM OF COPPER OR MANGANESE
郑飞波 1张珂 2吴淑荣 2李宁 2于江 2高希宝2
作者信息
- 1. 青岛市中心医院核医学科,山东青岛266042
- 2. 山东大学公共卫生学院
- 折叠
摘要
Abstract
Objective To study hearing impairment caused by chrome poisoning and its protection action of copper and manganese in rats. Methods Forty Wistar rats were evenly randomized to control group (physiological saline 4 mg/kg), chrome-poisoning group (potassium dichromate 4 mg/kg), copper-protection group (potassium dichromate 4 mg/kg and copper sul-fate 2 mg/kg) and manganese-protection group (potassium dichromate 4 mg/kg and manganese chloride 2 mg/kg). Continuous in-tragastric medication for 30 days, then the hearing of the rats were detected by auditory brainstem response (ABR). Results Compared with the control group, the ABR figures of chrome poisoning group were extremely flat, and the latency of both waves Ⅰand Ⅱ were obviously prolongated, and the peak of waves reduced dramatically (F = 3. 86 - 552. 67,q = 4. 30 - 55. 95,P< 0. 05). In copper-protection and manganese-protection groups, the latency period of waves I and II was shorter than chromium-poisoning group, the peak of wave was higher than that of the chrome-poisoning (q=3. 02 - 31. 48,P<0. 05), but did not yet return to the level of the control group. Conclusion Chromic poisoning may damage hearing in rats, and both copper and manganese show a certain protection of rats against from this impairment.关键词
铬/中毒/听觉丧失/铜/锰Key words
chromium/ poisonings hearing loss/ copper/ manganes分类
预防医学引用本文复制引用
郑飞波,张珂,吴淑荣,李宁,于江,高希宝..铬中毒致大鼠听力损伤及铜与锰对其的拮抗作用[J].青岛大学医学院学报,2011,47(6):498-500,3.
