中华耳科学杂志Issue(2)：187-191,5.
长病史感音神经性聋的药物疗效观察
Outcomes of pharmacological therapy in chronic sensorineural hearing loss
摘要
Abstract
Objective To report outcomes of medication treatment in patients with chronic sensorineural hearing loss (SNHL). Methods Twenty-eight patients with SNHL of 3 months to 17 years were treated with IV Ginaton (ginkgo biloba extracts), dexamethasone, and mecobalamin for 2 weeks, while 13 patients with SNHL of half to nineteen years received oral Ginkgo leaf, dehydrocortisone and mecobalamin for 2 weeks. Audiometry was performed before and after treatment on Days 3, 7, 10, 14, 30 and 60. Results In patients who received IV treatment, complete recovery was seen 2 cases (7.14%), significant improvement in 3 cases (10.71%), partial improvement in 13 cases (46.43%), and no effect in 10 cases (35.71%). Hearing improved in all patients with mild hearing loss in this group. The rate of improvement was 80% in patients with moderate hearing loss, 37.5% in those with severe hearing loss, and 62.5% in those with profound hearing loss. No complete recovery or significant hearing improvement was seen in patients receiving oral drugs. In this group, 4 (30.77%) showed partial improvement including 2 of the 3 patients with moderate hearing loss and 2 of the 6 with severe hearing loss, and 9 (69.23%) showed no effect. More improvement was seen in patients receiving IV treatment than those taking oral drugs (x2 = 4.01, P < 0.05). The maintenance of therapeutic effects was good in the two groups (P = 0.397). Conclusions There was therapeutic value for SNHL patients with long history. The therapeutic results would be better in patients with mild and moderate hearing loss than those with severe and profound SNHL. For patients with profound hearing loss, it' s suggested receiving drug treatment to improve the quality of hearing aid. The administration by intravenous injection should be the optimization.关键词
听觉丧失/感音神经性/长病史/药物疗法Key words
Hearing loss, sensorineural/Patient history, chronic/Drug therapy分类
医药卫生引用本文复制引用
王明明,樊兆民,韩月臣,宋姝霞,王海波..长病史感音神经性聋的药物疗效观察[J].中华耳科学杂志,2011,(2):187-191,5.基金项目
由国家自然科学基金青年科学基金项目(30801279)资助 （30801279）
