陕西医学杂志2011，Vol.40Issue(10)：1308-1310,3.
急性脑梗死患者血清S100B蛋白动态变化的临床研究
The dynamic changes of serum S100B protein content in patients with acute cerebral infarction
吴松笛 1韩仰东 1夏峰2
作者信息
- 1. 西安市第一医院,西安710002
- 2. 第四军医大学西京医院
- 折叠
摘要
Abstract
Objective: To investigate the dynamic changes and clinical significance of serum S100B protein content in patients with acute cerebral infarction (ACI). Methods:Dynamic measuring serum S100B protein content in patients with ACI at days 1, 3, 5, and 14 after onset by the use of enzyme-linked-immunosorbent serologic assay,and evaluating their association with the sizes of cerebral infarction and neural functional deficit degree in admission. Results :The serum S100B protein level increased significantly in patients with ACI at days 1, 3, and 5 after onset compared with control group (all P＜0. 01). The serum S100B protein content started to increase in patients with ACI at day 1, it kept at a high level until a peak appeared at day 3 and decreased to the same level as the control group at day 14 after onset. The level of serum S100B protein was significantly associated with the sizes of cerebral infarction and neural functional deficit degree in admission. Conclusion: The serum S100B protein can be used as a peripheral biochemical marker of brain injury. Determination of serum S100B protein content in patients with ACI has important reference value to determine the severity of the disease and assess prognosis after ACI.关键词
脑梗塞/预后/S100B蛋白Key words
Brain infarction/Prognosis/@S100B protein分类
医药卫生引用本文复制引用
吴松笛,韩仰东,夏峰..急性脑梗死患者血清S100B蛋白动态变化的临床研究[J].陕西医学杂志,2011,40(10):1308-1310,3.
