军医进修学院学报2011，Vol.32Issue(10)：1051-1054,1084,5.DOI:11-3275/R.20110519.1130.001
胃壁注射A型肉毒毒素对大鼠胃肌电和Cajal间质细胞的影响
Effects of introgastric injection with botulinum toxin A on gastric myoelectricity and interstitial cells of Cajal in rats
摘要
Abstract
Objective To study the effect of botulinum toxin A (BTX-A) on gastric myoelectricity and interstitial cells of Cajal (ICC). Methods Seventy-two rats were randomly assigned to 2-week group, 6-week group, and 12-week group, 24 in each group. Then, the rats in each group were randomly divided into control subgroup, BTX-A antral injection subgroup, BTX-A fundic injection subgroup, and BTX-A dotty injection subgroup, 6 rats in each subgroup, to observe the effect of BTX-A on their gastric myoelectricity and interstucal cells of Cajal(ICC) by gastroelectromyography, immunohistochemistry, and transmission electron microscopy(TEM). Results More significant bradygastria and rhythm disturbance, lower expression level of c-kit, severer dysplasia and worse abnormal network structure of ICC were observed by gastroelectromyography in 3 BTX-A injection subgroups than in control subgroup, which were more significant in BTX-A dotty injection subgroup followed by BTX-A fundic injection subgroup and BTX-A antral injection subgroup(P＜0.05). Two, six and twelve weeks after BTX-A injection, the difference among the 4 subgroups was gradually decreased. Twelve weeks after BTX-A injection, no difference was found in the above mentioned indications among the 4 subgroups. Conclusion Gastric BTX-A injection can lead to bradygastria and rhythm disturbance. The effect of BTX-A on ICC or their network structure is one of the important mechanisms underlying bradygastria, gastric myoelectricity and rhythm disturbance.关键词
A型肉毒毒素(BTX-A)/胃肌电/Cajal间质细胞(ICC)Key words
botulinum toxin A(BTX-A)/ gastric myoelectricity/ interstitial cells of cajal(ICC)分类
基础医学引用本文复制引用
陈英,刘庆森,刘文徽,孟科..胃壁注射A型肉毒毒素对大鼠胃肌电和Cajal间质细胞的影响[J].军医进修学院学报,2011,32(10):1051-1054,1084,5.基金项目
首都科学发展科研基金项目(2005-2043) （2005-2043）
