基础医学与临床2011，Vol.31Issue(10)：1139-1143,5.
聚乙二醇化干扰素α-2a对慢性乙型肝炎患者外周血T淋巴细胞亚群的影响
The effect of PGE-interferon-alpha2a on peripheral T lymphocyte subsets in Patients with chronic hepatitis B
阚晓 1隋赟 2韩绍磊 1曹创杰 1郑昭敏1
作者信息
- 1. 济南市传染病医院,山东济南250021
- 2. 济南市第二人民医院,山东济南250021
- 折叠
摘要
Abstract
Objective To study the change of peripheral T lymphocyte subsets and its impacton patients with chronic hepatitis B(CHB) during peginterferon-alph2a treatment. Methods Fifty-two patients with chronic hepatitis B were recruited and received peginterferon-alph2a treatment for 48 weeks. Before and during the 12 and 48 weeks of treatment, flow cytometry was used to detect the Peripheral T lymphocyte subsets. Realtime PCR was used to detect the level of HBV DNA. Markers of hepatitis B virus infection were detected by ELISA assay and level of alanine aminotransferase in the serum was measured by automatic biochemical analyzer. Results The proportion of peripheral blood CD4 +、D4+/ CD8 + in patients with CHB was significantly lower than that in healthy people( P <0. 05) and the proportion of peripheral blood CD8+T lymphocytes are increasing (P <0. 05). During 12 weeks of INFa treatment the proportion of peripheral blood CD4+ T lymphocytes and the ratio of CD4 + / CD8+ increased gradually, the proportion of peripheral blood CD8+ T lymphocytes decreased to normal level after 48 weeks INFa treatment. Treatment for 12 and 48 weeks with INFa resulted in HBeAg seroconversion to negative in 44. 2% patients and 51.9% patients respectively. In 11 (21. 1% ) patients who had seroconvertion from HBeAg to anti-HBeAg, after 12 months of INFa treatment, their proportion of peripheral blood CD4+、CD4+ / CD8+ had increased to level similar to that of the healthy people. Conclusions INFa treatment reduces HBV replication and increases the proportion of peripheral blood GD4+、CD4 + / CD8+ and these patients are prone to have higher sustain virus response and higher biochemical response.关键词
慢性乙型肝炎/淋巴细胞亚群/PEG-IFNα-2a/CD4+/CD8+Key words
chronic hepatitis B/ lymphocyte subsets/ peginterferon-alph2a/ CD4 + T lymphocytes/ CD8+T lymphocytes分类
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阚晓,隋赟,韩绍磊,曹创杰,郑昭敏..聚乙二醇化干扰素α-2a对慢性乙型肝炎患者外周血T淋巴细胞亚群的影响[J].基础医学与临床,2011,31(10):1139-1143,5.
