中国药业2011，Vol.20Issue(21)：36-38,3.
新藤黄酸固体脂质纳米粒的制备与质量评价
Preparation and Evaluation of Gambogenic Acid Solid Lipid Nanoparticles
陈延杰 1陈卫东1
作者信息
- 1. 安徽中医学院药学院,安徽合肥230038
- 折叠
摘要
Abstract
Objective To investigate the preparation and evaluation of gambogenic acid solid lipid nanoparticles. Methods The formulation was optimized through orthogonal design. Gambogenic acid solid lipid nanoparticles were prepared by the method of emulsification evaporation - solidification at low temperature. The encapsulation efficiency and appearance of solid lipid nanoparticles were studied. Results The mean particle size was found to be 163. 3 nm with a narrow particles distribution of polydispersity index. The drug entrapment efficiency approached (60. 1 ±1. 1)%. Conclusion The method of emulsification evaporation - solidification at low temperature was appropriate for the preparation of gambogenic acid loaded solid lipid nanoparticles.关键词
新藤黄酸/固体脂质纳米粒/高温乳化-低温固化Key words
gambogenic acid/ solid lipid nanoparticles/ emulsification evaporation - solidification at low temperature分类
医药卫生引用本文复制引用
陈延杰,陈卫东..新藤黄酸固体脂质纳米粒的制备与质量评价[J].中国药业,2011,20(21):36-38,3.
