中国肿瘤生物治疗杂志2011，Vol.18Issue(5)：467-472,6.DOI:10.3872/j.issn.1007-385X.2011.05.001
基因工程抗体片段——谱写抗体家族的新乐章
Genetic engineering antibody fragments -A novel tune for the antibody family
摘要
Abstract
With the advances in molecular biology and the clarification of antibody genetic structure, a variety of small-molecule antibody based-and genetic manipulated-genetic engineering antibody fragments have emerged and been widely used in scientific research, clinical diagnosis and therapy. Among which, bispecific antibody with combined biological activity and therapeutic targeting activity, immunoconjugate with enhanced function and targeting eytotoxicity, nanobody with special single domain structure which is widely applied in biological technology and clinical research, and intrabody with special intracellular expression are the most active fields in antibody fragment research. Genetic engineering antibody fragments have received extensive attention and approval over full-length monoclonal antibodies owing to their desirable characteristics, such as weak immunogenicity, strong tissue permeability, minimal toxicity and simple preparation, although the safety and efficiency of most antibody fragments in clinical research still need to be further identified, development of scientific research on genetic engineering antibody fragments, will inevitably improve diagnosis and therapy of human diseases.关键词
抗体片段/基因工程/双特异性抗体/免疫结合物/纳米抗体/细胞内抗体/抗肿瘤作用Key words
antibody fragment/ genetic engineering/ bispecific antibody/ immunoconjugate/ nanobody/ intrabody/ anti-tumor effect分类
医药卫生引用本文复制引用
崔恒,高磊..基因工程抗体片段——谱写抗体家族的新乐章[J].中国肿瘤生物治疗杂志,2011,18(5):467-472,6.基金项目
国家自然科学基金资助项目(No.30872750) （No.30872750）
