中国药业2011，Vol.20Issue(21)：40-42,3.
小儿遗尿分散片的制剂处方筛选与α-细辛醚、β-细辛醚含量测定
Formula Optimization of Xiaoer Yiniao Dispersible Tablets and Content Determination of a - Asarone and - Asarone in the Tablets
摘要
Abstract
To optimize the formulation and preparation process of Xiaoer Yiniao Dispersible Tablets, and to establish an HPLC method for determination of a - asarone and (3 - asarone in the tablets. Methods The prescription of Xiaoer Yiniao Dispersible Tablets were optimized by parallel design technique, with disintegrating time, appearance and taste as the assessment index. The analytical column was packed with Hypersil ODS ', 250 mm x 4. 6 mm.5 fim) and performed at 30 T!. The mobile phase was consisted of methanol - water (60 : 40). The How rate was 1. 0 mL/min. Results The dispersible tablets prepared fine in appearance and taste, disintegrated within 60s. - asarone and J3 - asarone were linear in the range of 0. 054 - 1. 286 g/L and 0. 187-4. 672 g/L respectively. The average recovery was 101.48% and 99.65% with RSD of 1.07% and 1. 31% ( n - 6) .respectively. Conclusion The dispersible tablets were designed rationally and feasible to operate. HPLC method was simple,accurate and specific.关键词
小儿遗尿分散片/高效液相色谱法/α-细辛醚/β-细辛醚Key words
Xiaoer Yiniao Dispersible Tablets/HPLC/a. - asarone /p - asarone分类
化学化工引用本文复制引用
陈日来,陈泽彬,李玉珍,罗奇志,李成,朱锦善..小儿遗尿分散片的制剂处方筛选与α-细辛醚、β-细辛醚含量测定[J].中国药业,2011,20(21):40-42,3.基金项目
深圳市科技计划项目(医疗卫生类),项目编号:200803057 （医疗卫生类）
深圳市福田区2008年科技计划项目,项目编号:FTWS043. （）
