疑难病杂志2011，Vol.10Issue(12)：909-911,3.DOI:10.3969/j.issn.1671-6450.2011.12.014
原发性干燥综合征合并肺间质病变临床特点分析
Clinical analysis of primary Sj(o)gren syndrome combined with interstitial lung disease
吉恒东 1邹红梅 1林静 1路峰1
作者信息
- 1. 225300,江苏泰州,南通大学附属泰州市人民医院风湿免疫科
- 折叠
摘要
Abstract
Objective To investigate the clinical characteristics, treatment and prognosis of primary Sjogren syndrome ( PSS ) combined with interstitial lung disease ( ILD ). Methods 84 patients with PSS were divided into two groups ( ILD group: n =24,non-ILD group: n =63 ). Retrospective analysis were carried out according to the time of onset, clinical course, laboratory test, imaging examination and condition of treatment and prognosis in the two groups separately. Results The age of onset and courses of disease in ILD group were elder and longer than patients in non-ILD group( P < 0. 05 ). The ESR, CRP level and RF, anti SSA antibodies, plasma protein, anti U1RNP antibody positive rates in the ILD group were significantly higher than those in non-ILD group( P <0. 05 ). Patients in ILD group had abnormal pulmonary HRCT results. All of the patients in ILD group were given corticosteroid and immunosuppressant cyclophosphamide therapy for 6 months. Clinical symptoms and / or pulmonary function were improved with diiierent degrees in 20 patients, no improvement were found in 2 cases and progressive in 2 cases. Conclusion Pulmonary HRCT is useful in the early diagnosis of PSS combined with interstitial lung disease. Early stage standardized treatment is helpful for the improvement of prognosis.关键词
干燥综合征,原发性/肺病,间质性/临床特征Key words
Sjogren syndrome,primary/Lung disease,interstitial/Clinical characteristics引用本文复制引用
吉恒东,邹红梅,林静,路峰..原发性干燥综合征合并肺间质病变临床特点分析[J].疑难病杂志,2011,10(12):909-911,3.
