中国肿瘤生物治疗杂志2011，Vol.18Issue(5)：524-527,4.DOI:10.3872/j.issn.1007-385X.2011.05.011
胃癌组织中烯醇化酶-α和肿瘤型丙酮酸激酶蛋白的表达及其临床意义
Expression of enolase-α and tumor M2 pyrurate kinase in gastric cancer and their clinical significances
摘要
Abstract
Objective: To investigate the expression, correlation and clinicopathological significance of enolase-a (ENO1) and tumor M2 pyruvate kinase (M2-PK) in gastric cancer. Methods; Seventy-eight paraffin-embedded specimens of gastric tissues (55 gastric cancer and 23 gastric ulcer tissues) from the First Hospital of Lanzhou Universtiy (Jun. 2009 to Oct. 2010) were included in the present study. Expression of ENO1 and M2-PK in gastric cancer and gastric ulcer tissues were detected by S-P immunohistochemistry. Correlation between ENO1 expression and M2-PK expression, and its implication in the clinicophathologic features of gastric cancer were analyzed. Results; The positive expression rate of ENO1 in gastric cancer tissues was significantly higher than in gastric ulcer tissues (67.3% vs 30.4% , P <0.01), and positively related to differentiation grade, depth of invasion, lymph node metastasis and TNM staging ( all P < 0.05). The positive expression rate of M2-PK in gastric cancer tissues was significantly higher than in gastric ulcer (78. 2% vs 39. 1 % , P < 0.01) , and positively related to differentiation grade (P < 0.05 ) , depth of invasion ( all P < 0.05). Expression of ENO1 was positively correlated to that of M2-PK ( r = 0.5729, P < 0.05 ). Conclusion; The up-regulated expression of ENO1 and M2-PK may participate in the oncogenesis and progression of gastric cancer. Combined detection of ENO1 and M2-PK in gastric cancer tissues may be helpful in evaluating the prognosis of gastric cancer.关键词
胃癌/烯醇化酶-α/肿瘤型丙酮酸激酶/免疫组化Key words
gastric cancer/ enolase-a/ tumor M2 pyruvate kinase/ immunohistochemistry分类
医药卫生引用本文复制引用
倪田根,高晨,周欣,王娜,曾峰,关泉林..胃癌组织中烯醇化酶-α和肿瘤型丙酮酸激酶蛋白的表达及其临床意义[J].中国肿瘤生物治疗杂志,2011,18(5):524-527,4.基金项目
中央高校基本科研业务费专项基金资助(lzujbky-2010-143). （lzujbky-2010-143）
