中国药房2011，Vol.22Issue(39)：3677-3679,3.
葛根素固体自微乳制剂的制备及其质量评价
Preparation of Puerarin Solid Self-microemulsifying Drug Delivery System and Quality Evaluation of It
摘要
Abstract
OBJECTIVE: To prepare Puerarin solid self-microemulsifying drug delivery system (SMEDDS), and to evaluate its quality. METHODS: The influencing factors of the efficiency of self-emulsifying and the particle size were investigated by changing the formulation composition, dilution,medium, temperature etc. The particle size was determined by the laser particle size analyzer, and the morphology was investigated by TEM. Besides, the stability of Puerarin solid SMEDDS was studied by 3 months of accelerated test. RESULTS: The composition, temperature, etc. Had some impactions to the efficiency of self-emulsifying and particle size, but the dilution, dispersion, etc. Had little effect in a certain range. Puerarin solid SMEDDS was round after it was dissolved into ME and the average diameter was 30 nm. CONCLUSION: Puerarin solid SMEDDS are stable with small particle size.关键词
葛根素/自微乳化效率/固体自微乳Key words
Puerarin/ Efficiency of self-microemulsifying/ Solid self-microemulsifying drug delivery system分类
医药卫生引用本文复制引用
孙洪胜,傅春升,张红艳..葛根素固体自微乳制剂的制备及其质量评价[J].中国药房,2011,22(39):3677-3679,3.基金项目
山东省中医药科技发展计划项目(2009-086) （2009-086）
