中国药房2011，Vol.22Issue(40)：3769-3772,4.
性别差异对服用氢氯噻嗪后不同ACE基因型高血压患者血清RAAS活性变化的影响
Effects of Gender Difference on the Activity of RAAS Responding to Hydrochlorothiazide in Hypertensive Patients with Different ACE Genotypes
摘要
Abstract
OBJECTIVE: To evaluate effects of gender difference on renin angiotensin aldosterone system (RAAS) in response to hydrochlorothiazide (HCTZ) in hypertensive patients with different angiotensin converting enzyme (ACE) genotypes. METHODS: We enrolled randomly 829 mild/moderate hypertensive patients. All subjects stop taking previous antihypertensive drugs. After 2 weeks of wash-out period with placebo, every subject had been orally given 12.5 mg HCTZ, once a day for next 6 weeks. The activity of RAAS was determined after treatment. The interaction between genotypes at ACE I/D polymorphism and gender was analyzed. RESULTS: A total of 776 patients completed the study. In male, the increases of serum ACE and Ang II activity in patients with DD genotype after HCTZ were greater than those in patients with II and ID genotypes (P<0.05). However, in female, the increases of serum ACE and Ang II activity in patients with DD genotype after HCTZ were lower than those in patients with II and ID genotypes (/><0.05). There was statistically significant interaction of ACE gene I/D polymorphism and gender with changes of serum ACE activity (f=0.032), and the marginal interaction between the effects of them and changes of serum Ang II activity (P=0.070). CONCLUSION: There was statistically significant interaction of ACE gene I/D polymorphism and gender with changes of serum ACE activity after adjusting age, BMI, and baseline blood pressure.关键词
性别/高血压血管紧张素转换酶基因/氢氯噻嗪/肾素-血管紧张素-醛固酮系统/交互作用Key words
Gender/ Hypertensive ACE gene/ Hydrochlorothiazide/ Renin-angiotensin-aldosterone system/ Interaction分类
医药卫生引用本文复制引用
李云,张江,许绍忠,杨鹏,徐胜,吴寿岭,赵丹丹,武英,赵丽萍,孙满江,褚立明..性别差异对服用氢氯噻嗪后不同ACE基因型高血压患者血清RAAS活性变化的影响[J].中国药房,2011,22(40):3769-3772,4.基金项目
国家自然科学基金资助项目(81000110) （81000110）
