摘要
Abstract
OBJECTIVE: To review the effect and safety of compound Sophora flavescens injection for the treatment of non-small cell lung cancer(NSCLC). METHODS: We set include and exclude criterion, and searching strategy, databases of PubMed, EMBase, Cochrane, CBM, VIP, Wanfang, CNKI were searched, randomized trials (RCT) of compound S. Flavescens combined with the third generation chemotherapy drugs and platinum for the treatment of NSCLC were gathered. Quality was evaluated and meta-analysis was carried out. RESULTS: 16 RCT were included. Meta-analysis indicated that the differences of total effect rate[RR=1.35,95%CI(1.09,1.69) ;RR=1.25,95%CI( 1.02,1.53)], life of quality improvement rate[RR=1.67,95%Cl( 1.35, 2.07);RR=1.98,95%CI(1.51,2.59)], leucopenia ( ffl~IV)[RR=0.49,95%CI(0.35,0.69);RR=0.57,95%CI(0.37,0.88)], gastrointestinal reaction (I~lV)[RR=0.58,95%CI(0.41,0.83); RR=0.45,95 %CI( 0.30,0.68)] and baldness in NP and TP group combined with compound S. Flavescens were significant. And compound S. Flavescens combined with GP trended to be the same effect above. CONCLUSION: Based on current evidence, compound S. Flavescens combined with NP, TP could improve short term effectiveness and decrease toxic and side-effects; long term effectiveness is hoped.关键词
复方苦参注射液/非小细胞肺癌/Meta分析Key words
Compound Sophora flavescens injection/ Non-small cell lung cancer/ Meta-analysis分类
医药卫生
