山东医药2011，Vol.51Issue(31)：19-21,3.
腋窝淋巴结阴性乳腺癌组织中PTEN、p-Akt、P-gp表达及意义
Expression and significance of p-Akt, PTEN and P-gp in patients with axillary node negative breast cancer
摘要
Abstract
Objective To investigate the effects of phospho-Akt ( p-Akt) , phosphatase and tensin homolog deleted on chromosome ten(PTEN) and P-glycoprotein(P-gp)in the occurrence and development of breast cancer. Methods A series of 81 primary axillary lymph node negative ( LNN) breast cancer specimens were performed by immunohistochemical staining to detect the expression of p-Akt, PTEN and P-gp. The correlation between the three indexes and clinicopathologi-cal factors of breast cancer were analyzed by x2-test, exact propability and Cox 's proportional hazard model. Results A marked increased activity of p-Akt was detected in breast cancer, which was significantly higher than that in normal breast tiasues(P=0,034). The PTEN expression was 63.0% , which was significantly lower than that in normal tissues(P = 0.001). The overexpression of p-Akt and loss of PTEN was related with tumor differentiation, ER negative, recurrence, metastasis and 5-years survival rates. The positive rate of P-gp was 39.5% , related with recurrence and distant metastasis. Multivariate analysis found that p-Akt expression was also signigicantly positively correlated with P-gp expression ( r = 0.548,P=0.045) , and also expression of p-Akt (F=0.04) and PTEN (P=0.02) were independent prognostic factors for prognosis of LNN breast cancer. Conclusions P-Akt, PTEN and P-gp may play certain effects in the occurrence and development of breast cancer, to detect the level of the three indexes is helpful for the prognosis evaluation.关键词
乳腺肿瘤/磷酸化Akt/人第10号染色体缺失的磷酸酶及张力蛋白同源的基因/P-糖蛋白Key words
breast tumor/ phospho-Akt/ phosphatase and tensin homolog deleted on chromosome ten/ P-glycoprotein分类
医药卫生引用本文复制引用
王爱英,林晓燕,王强修,李加美..腋窝淋巴结阴性乳腺癌组织中PTEN、p-Akt、P-gp表达及意义[J].山东医药,2011,51(31):19-21,3.基金项目
出东省优秀中青年科学家科研奖励基金资助项目(BS2009YY033). （BS2009YY033）
