摘要
Abstract
OBJECTIVE: To evalute the clinical efficacy and safety of Aidi (AD) injection combined with chemotherapy in the treatment of colorectal cancer, and to provide evidence-based basis for rational drug use in the clinic. METHODS: We searched CMCC, CNKI, PubMed, Medline, EMBase, Google Scholar and the Cochrane Library. RESULTS: There were 8 selected literatures, including 551 cases, of which 279 patients were in AD group and 272 patients were in control group. Compared with control group, quality of life was improved by 28.10%[OR=0.39, 95%CI(2.62,5.81),P2<0.000 01] in AD group. Complications like leucocyte toxicity and sensory neuropathy were lowered by 23.80%[OR=0.41, 95%CI(0.19,0.86), P2=0.02] and 11.33%[OR= 0.25, 95%CI(0.15,0.43), P2<0.000 01] in AD group respectively. CONCLUSION: AD injection can improve quality of life and lower complications in the treatment of CRC. Results of study is reliable verified by sensitivity analysis.关键词
艾迪注射液/结直肠癌/生存质量/并发症/Meta分析Key words
Aidi injection/ Colorectal cancer/ Quality of life/ Complications/ Meta-analysis分类
医药卫生
