医药导报2011，Vol.30Issue(12)：1546-1548,3.DOI:10.3870/yyb.2011.12.002
氟哌啶醇对氯胺酮所致小鼠条件性位置偏爱的影响
Impact of Haloperidol on Conditional Place Preference Induced by Ketamine in Mice
摘要
Abstract
Objective To investigate the effects of haloperidol ( H ) on conditional place preference induced by ketamine ( K ) in mice. Methods Forty mice enrolled were randomly divided into 4 groups ( n = 10 ): control group ( NS group ), ketamine group ( K group ), ketamine plus haloperidol ( 0. 33 mg ? Kg'1 ) group ( KH, group ) and ketamine plus haloperidol ( 1. 0 mg ? Kg'1 ) group ( KH2 group ). The conditional place preference ( CPP ) tests were carried out in each mouse and the duration of staying in the white box 24 hours before and after withdrawal. Results The basic duration for 24 hours before withdrawal in group NS,K,KH, and KH, was ( 157. 38±68. 75 ),( 197. 78±90. 16 ),( 190. 11±127. 47 ) and ( 244.00± 127. 88 ) s,respectively; that for 24 hours after withdrawal was ( 316. 25±263. 52 ),( 337. 44±152. 92 ),( 324. 44±172. 61 )and ( 317. 56±165. 85 ) s,respectively. Compared with the basic duration within group,the duration of staying in the white box after withdrawal for group K or group KHj prolonged ( P<0. 05 ),but no statistically significant difference ( P>0. 05 ) was found for group KH2. Conclusion Haloperidol may interfere with the conditional place preference induced by ketamine in mice, which implies that it may lessen the psychic dependence caused by ketamine.关键词
氟哌啶醇/氯胺酮/位置偏爱,条件性/精神依赖性/小鼠Key words
Haloperidol/ Ketamine/ Place preference, conditional/ Psychic dependence/ Mice分类
医药卫生引用本文复制引用
丁晓维,史兰芃,蒋道猛,徐小艳,周涵,戚灿,熊振天,马涛..氟哌啶醇对氯胺酮所致小鼠条件性位置偏爱的影响[J].医药导报,2011,30(12):1546-1548,3.基金项目
江苏省高校自然科学基础研究基金资助项目(基金编号:09KJB320019) （基金编号:09KJB320019）
宁波市自然科学基金资助项目(基金编号:2009A610140) （基金编号:2009A610140）
