中国实用内科杂志Issue(10)：780-782,3.
异基因造血干细胞移植后应用伊曲康唑肝功能异常53例病因分析
Liver dysfunction in patients with itraconazole after allogeneic hematopoietic stem cell transplantation:a 53-case etiological analysis.
摘要
Abstract
Objective To analyze the clinical etiology and the characteristics of liver dysfunction in patients with itraconazole after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods We retrospectively analyzed the clinical etiology and features of liver dysfunction in 53 patients who took itraconazole after allo-HSCT. Results The clinical cause of liver dysfunction was associated with graft-versus-host disease (GVHD) in 14 patients (26. 4% ) ,with infection,in 13 (24. 5% ) , with regimen-related toxicity in 11 (20. 8% ) ,with drugs in 8 (15. 1% ) ,with thrombotic microangiopathy (TMA) in 1 case ( 1. 9% ) ,with sinusoidal obstruction syndrome ( SOS) in 1 case ( 1. 9% ) respectively. The cause was still to be explored in 5 cases (9. 4% ). In GVHD group, the ratio of simultaneously increased liver enzyme and bilirubin was significantly higher than the infection related group ( P = 0. 007 ) , and incidence of grade 4 liver dysfunction was higher than the regimen-related toxity related group ( P = 0. 021 ). Conclusion The most common causes of liver dysfunction in patients with itraconazole after Allo-HSCT were GVHD, infection, regimen-related toxicity, drug-induced abnormalities and other undetermined factors.关键词
造血干细胞移植/异基因/肝功能异常/伊曲康唑Key words
hematopoietic stem cell transplantation/allogeneic/liver dysfunction/itraconazole分类
医药卫生引用本文复制引用
张熙洋,许兰平,黄晓军,王昱,莫晓冬,王景枝,刘代红..异基因造血干细胞移植后应用伊曲康唑肝功能异常53例病因分析[J].中国实用内科杂志,2011,(10):780-782,3.基金项目
中华医学会-西安杨森-抗真菌感染专项研究资金(2009年) （2009年）
“十一五”国家科技支撑计划课题(2008BA161B01) （2008BA161B01）
