肿瘤防治研究Issue(9)：1042-1045,4.DOI:10.3971/j.issn.1000-8578.2011.09.017
垂体肿瘤转化基因在大肠正常黏膜、腺瘤及大肠癌组织中的表达及意义
Expression of PTTG in Normal Mucosa, Adenoma and Colorectal Carcinoma
摘要
Abstract
Objective To explore the role of PTTG expression in the occurrence and development of color-ectal carcinoma. Methods RT-PCR technique was used to examine mRNA expression of PTTG and immunohistochemical staining was used to examine protein expression of PTTG in 20 cases of normal mucosa> 20 cases of adenoma and 80 cases of colorectal carcinoma tissues. Results Expression of PTTG at mRNA and protein appeared an upward tendency in the order from normal mucosa and adenoma to colorectal carcinoma and the differences was significant between any two groups(P<0. 01). Expression of PTTG at mRNA and protein was also positively correlated with depth of invasion, lymph node metastasis (P<0. 05 and P<0, 01, respectively). Conclusion The high expression of PTTG may play an important role in the occurrence and development of colorectal cancer.关键词
大肠癌/垂体肿瘤转化基因/反转录聚合酶链式反应/免疫组织化学Key words
Colorectal Carcinoma/ PTTG/ RT-PCR/ Immunohistochemistry分类
医药卫生引用本文复制引用
申兴斌,段惠佳,赵杨,张古林..垂体肿瘤转化基因在大肠正常黏膜、腺瘤及大肠癌组织中的表达及意义[J].肿瘤防治研究,2011,(9):1042-1045,4.基金项目
河北省科技厅资助课题(08276101D-10) （08276101D-10）
