中国病理生理杂志2011，Vol.27Issue(11)：2170-2174,5.DOI:10.3969/j.issn.1000-4718.2011.11.025
小鼠对雨蛙肽诱发急性胰腺炎易感性的品系差异
Strain difference of susceptibility to caerulein-induced acute pancreatitis in mice
摘要
Abstract
AIM: To study the difference of susceptibility to caerulein - induced acute pancreatitis ( AP) among the mice of C57BL/6J, BALB/c and ICR strains. METHODS; Two - month - old female mice of C57BI/6J, BALB/c and ICR strains (12 mice for each strain) were divided into control group (re =6) and experimental group (n = 6) , respectively. The mice were intraperitoneally injected with caerulein (50 μg/ kg) in 1 h interval for 7 serial injections in total. The mice in- control group were treated with saline according to the same procedure in experimental group. The blood samples were collected at0h,3h,6h,9h, 12 h and 24 h after the first injection of caerulein or saline for plasma a - amylase and lipase assays. The mice were sacrificed 24 h after AP induction, and the pancreatic tissues were harvested for further investigating the pathological changes and expression of inflammatory factors. RESULTS; After AP induction, the mice of BALB/c and ICR strains demonstrated more dramatic increase in plasma a - amylase activity and lipase activity than those of CS7BL/6J mice. C57BL/6J mice showed milder morphological changes and lower expression of inflammatory factors in pancreata than those of BALB/c and ICR mice. CONCLUSION; The mice of CS7BL/6J strain have less susceptibility to caerulein - induced AP than that of BALB/c and ICR mice.关键词
小鼠品系/雨蛙肽/急性胰腺炎/易感性Key words
Mouse strains/ Caerulein/ Acute pancreatitis/ Susceptibility分类
医药卫生引用本文复制引用
张化宇,唐寅,常青,刘璐,王宇辉,蒋孟茜,韩迎春,祁荣,刘国庆..小鼠对雨蛙肽诱发急性胰腺炎易感性的品系差异[J].中国病理生理杂志,2011,27(11):2170-2174,5.基金项目
国家自然科学基金资助项目(No.30971241) （No.30971241）
