摘要
Abstract
Objective To study clinicopathologjc features and to enhance the acquaintance of granular cell tumor (GCT). Methods Fourteen cases were collected from Enze Medical Center Taizhou Hospital from 2006 to 2010 and analyzed with review of clinical data and pathologic features. Results The main presenting symptom was painless nodule and located in the subcutis or deep soft tissue. The tumors occurred in the esophagus in 6 patients, in the waist and chest back in 3, and in the low left abdominal wall, upper left arm, scrotum, left superior lobar bronchus, right superior lobar bronchus in one each. The tumor size ranged from 0. 3 - 4 cm (mean size =1.3 cm). Microscopically, the tumor was composed of nests or sheets of polygonal or round cells which were full of abundant eosinophilic granular cytoplasm. Immunohistochemically,the tumor cells were positive for S-100,NSE, weak positive in one case for CD68,while negative for Desmin.CK. Thirteen cases had typical histological features, while one case had atypical features. Growth patterns were invasive in 8 cases and expansive in 6, including 1 atypical case. Recurrence or metastasis was not detected in all 11 cases during 5-38 months of follow-up. Conclusions GCT is a rare neoplasm of soft tissue originated from Schwann cell, and may locate in every part of the body. Clinically and morphologically GCT is easy to misdiagnose.and the immunohistochemistry is helpful for the differential diagnoses.关键词
颗粒细胞瘤/病理学/软组织肿瘤/诊断,鉴别/随访研究/免疫组织化学Key words
granular cell tumor/pathology/ soft tissue neoplasm/ diagnosis, differential/ follow-up studies/ immunohistochemistry分类
医药卫生
