中国药理学与毒理学杂志2011，Vol.25Issue(5)：487-489,3.DOI:10.3867/j.issn.1000-3002.2011.05.014
扩展的简单串联重复位点诱发突变在遗传毒理学的应用进展
Expanded simple tandem repeat loci induced mutation in genetic toxicology and its progress
摘要
Abstract
Expanded simple tandem repeats (ESTRs) are unstable tandem repetitive DNA loci , which are applied largely in induced mutation of germline, because of the high spontaneous mutation rate. So far,three types of repeat sequences have been found. They are named a small satellite, microsatellite and ESTRs, respectively. While pedigree and single-molecule PCR are used to monitor changes in repeat sequences . However, the mutation mechanisms of these repeat sequences are exactly unknown till now. So, in this paper reviewed, the similar and differences of three different repeatitive loci, the advantages and disadvantages of the two methods , as well as the mutation mechanism were focused.关键词
串联重复序列/等位基因/突变/系谱/聚合酶链反应Key words
tandem repeat sequences/alleles/mutation/pedigree/polymerase chain reaction分类
生物科学引用本文复制引用
梁春柳,姚朗,张天宝..扩展的简单串联重复位点诱发突变在遗传毒理学的应用进展[J].中国药理学与毒理学杂志,2011,25(5):487-489,3.基金项目
上海市公共卫生重点学科建设项目(08GWZX0301) （08GWZX0301）
