南京医科大学学报（自然科学版）2011，Vol.31Issue(9)：1285-1288,1390,5.
麇鹿角醇提液对环磷酰胺致雄鼠性腺损伤的保护作用
摘要
Abstract
Objective:To observe the protective effect of Elk antlers ethanolic fluidextract (EAEF) on gonad function impairment of male mice induced by cyclophosphamide (CP). Methods;The model of gonad function depression was prepared by repeatedly in-traperitoneal injection of CP. Low and high dose of EAEF were given to mice with oral administration to intervene this process,then the level of testosterone and luteinizing hormone in serum were detected;the weight index of sex organ and accessory sex organ were observed;sperm density and sperm activity were detected;the superoxide dismutase (SOD) activity and malonaldehyde(MDA) content were measured. Meanwhile the histopathological changes in testis were observed by light microscopy. Results;EAEF reversed the decline of testosterone and luteinizing hormone level in serum,enhanced the testicle mass index,sperm density and sperm activity, increased SOD activity and decreased content of MDA in testis,as well alleviated the histologic pathological formation in testis in cyclophosphamide-induced model mice. Conclusion;EAEF has protective effect on gonad dysfunction impairment of male mice induced by CP, which might be related to it's the gonadotropin hormone-like effect and antioxidation.关键词
麋鹿角醇提液/环磷酰胺/性腺/睾酮/黄体生成素/超氧化物歧化酶/丙二醛/抗氧化Key words
Elk antlers ethanolic fluidextract (EAEF)/cyclophosphamide/gonad/testosterone/luteinizing hormone/superoxide dismutase (SOD)/malonaldehyde (MDA)/antioxidation分类
医药卫生引用本文复制引用
成海龙,陈鹤林,韩中保,田郡,陆晓东,秦红兵..麇鹿角醇提液对环磷酰胺致雄鼠性腺损伤的保护作用[J].南京医科大学学报（自然科学版）,2011,31(9):1285-1288,1390,5.基金项目
盐城市科学技术局项目(YK2010113) （YK2010113）
