外源性IL-23对病毒性心肌炎小鼠Th17细胞增殖的影响OA北大核心CSCDCSTPCD
The effects of exogenous IL-23 on the proliferation of Th17 cells in vitro in the mice model of virus myocarditis
目的:观察小鼠重组IL-23(rIL-23)对病毒性心肌炎(VMC)小鼠Th17细胞增殖的影响.方法:BALB/c小鼠腹腔注射柯萨奇病毒B3(CVB3)建立VMC小鼠模型,1周后磁珠分离脾CD4+T淋巴细胞后进行体外培养,分别加入植物血凝素(PHA)与重组小鼠IL-23(rIL-23)或PHA单独刺激进行体外培养5天.流式细胞术测定培养后Th17细胞占CD4细胞的百分比、RT-PCR测定培养细胞IL-17 mRNA的表达、ELISA法测定培养物上…查看全部>>
Objective:To observe theThl7 proliferation in 1he mice model of virus myocarditis(VMC) stm ulated by ream binant L-23 (rL-23) in vito.M e1hods:VMC was induced in maleBALB/cmieby ooxsackie virusB3 (CVB3)peri1onealinJ3ction(I.p) .Spleen CD4+ T cells were purified using a CD4 T cell isolation kit 1 week after inaction. Isolated CD4 T cells were cultured wilh phytohan agglutinin (PHA ) plus rL-23 orPHA alone fer5d in vitro .After culture,flow cytemetric analysis…查看全部>>
杨帆;伍伟锋;颜玉鸾;庞羽;孔清
广西医科大学第四附属医院柳州市工人医院心内科,柳州,545005广西医科大学第一附属医院心内科,柳州,545005广西医科大学第一附属医院心内科,柳州,545005广西医科大学第一附属医院心内科,柳州,545005广西医科大学第一附属医院心内科,柳州,545005
医药卫生
心肌炎IL-23Th17细胞
M yocarditis L-23 Thl7
《中国免疫学杂志》 2011 (11)
1018-1021,4
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