首页|期刊导航|中国神经再生研究（英文版）|Hippocampal mitochondrial cytochrome C oxidase activity and gene expression in a rat model of chronic cerebral ischemia
中国神经再生研究（英文版）2011，Vol.6Issue(32)：2527-2531,5.DOI:10.3969/j.issn.1673-5374.2011.32.009
Hippocampal mitochondrial cytochrome C oxidase activity and gene expression in a rat model of chronic cerebral ischemia
Hippocampal mitochondrial cytochrome C oxidase activity and gene expression in a rat model of chronic cerebral ischemia
摘要
Abstract
The present study established a rat model of chronic cerebral ischemia using bilateral common carotid artery permanent ligation to analyze cytochrome C oxidase activity and mRNA expression in hippocampal mitochondria.Results showed significantly decreased cytochrome C oxidase activity and cytochrome C oxidase II mRNA expression with prolonged ischemia time.Further analysis revealed five mitochondrial cytochrome C oxidase II gene mutations, two newly generated mutations, and four absent mutational sites at 1 month after cerebral ischemia, as well as three mitochondrial cytochrome C oxidase III gene mutations, including two newly generating mutations, and one disappeared mutational site at 1 month after cerebral ischemia.Results demonstrated that decreased cytochrome C oxidase gene expression and mutations, as well as decreased cytochrome C oxidase activity, resulting in energy dysmetabolism, which has been shown to be involved in the pathological process of ischemic brain injury.关键词
cerebral ischemia/cytochrome C oxidase/gene mutation/hippocampus/mitochondrion/neural regenerationKey words
cerebral ischemia/cytochrome C oxidase/gene mutation/hippocampus/mitochondrion/neural regeneration引用本文复制引用
Qing Zhao,Yingli Zhang,Mingming Zhao,Yu Wang,Ming Ma,Xinquan Gu,Xia Cao..Hippocampal mitochondrial cytochrome C oxidase activity and gene expression in a rat model of chronic cerebral ischemia[J].中国神经再生研究（英文版）,2011,6(32):2527-2531,5.基金项目
the International Cooperation Program of Science and Technology Department of Jilin Province,No.20100751 （）
