南京医科大学学报（自然科学版）2011，Vol.31Issue(7)：1027-1031,5.
完全胸腔镜与开放性肺叶切除术治疗的非小细胞肺癌患者围手术期IGFBP-3、VEGF、IL-6水平的比较
Comparison of the perioperative levels of IGFBP-3,VEGF,IL-6 between totally video-assisted thoracoscopic surgery and traditional open surgery in non-small cell lung cancer patients
摘要
Abstract
Objective:To compare perioperative effect of lobeclomy by totally video-assisted thoracoscopic surgery (tVATS) or traditional open surgery(TOS) on immunologic function and prognostic factors of non-small cell lung cancer(NSCLC) patients. Methods:Forty NSCLC patients underwent lobectomy by TOS or tVATS were selected,20 patients in each group. The serum levels of interleukin-6(IL-6), insulin-like growth factor binding protein-3(IGFBP-3) and vascular endothelial growth factor (VEGF) of patients before surgery and at the 1st,3rd and 5th day after surgery were determined using the ELISA. At the same time,the clinical data were collected and compared between two groups. Results;There was no significant difference in the preoperative serum levels of IL-6,IGFBP-3 and VECF between two groups. The levels of IL-6 and VECF at the three postoperative time points in tVATS group were significantly lower than those in TOS group. The levels of ICFBP-3 at the three postoperative time points in tVATS group were significantly higher than those in TOS group. There were no death and no serious complications in two groups. No conversion to thoracotomy occurred in tVATS group. There was no significant difference in operative time,numbers of stations and numbers of lymph node dissected,the chest drainage days and drainage volume after surgery between two groups. In tVATS group,intraoperative blood loss,postoperative pain score,days of getting out of bed and postoperative hospital stay were significantly lower than those in TOS group. Conclusion: Comparing with TOS, the effect of lobectomy with tVATS on the immune suppression and the influence on tumor metastasis and recurrence is much less. It can improve the prognosis of patients,provide favorable conditions for the subsequent treatment关键词
肺叶切除术/电视胸腔镜/免疫抑制/IL-6/IGFBP-3/VEGFKey words
lobectomy/tVATS/immune suppression/IL-6/IGFBP-3/VEGF分类
医药卫生引用本文复制引用
蒲振业,陈亮,朱全,潘世扬,秦雪君..完全胸腔镜与开放性肺叶切除术治疗的非小细胞肺癌患者围手术期IGFBP-3、VEGF、IL-6水平的比较[J].南京医科大学学报（自然科学版）,2011,31(7):1027-1031,5.基金项目
江苏省科技厅社会发展项目(BS2007073)；江苏省卫生厅重大攻关课题(H200007) （BS2007073）
