南京医科大学学报（自然科学版）2011，Vol.31Issue(8)：1169-1172,4.
1H-MRS动态监测乳腺癌患者化疗后的肝脏脂肪含量的变化
Using 1H magnetic resonance spectroscopy to monitor liver fat changes due to chemotherapy in breast cancer patients
摘要
Abstract
Objective:To explore the feasibility of monitoring liver fat content changes by proton maganetic resonance spectroscopy (1H-MRS) in patients with cancer of mammary gland. Methods:Thirty patients with breast cancer who were receiving postoperative chemotherapy were included. 1H-MRS was acquired before chemotherapy,after three or six cycles treatment. All scans were performed on GE 1.5T MRI system using point-resolved-spectroscopy sequence,and breathing gating were employed. Fat content was calculated by measuring the areas of water and lipid peaks using jMRUI software package. Results:Hepatic fat content increased in 26 patients (26/30) after treatement. Among these patients 21 cases had lipid peak before treatment and the value increased from (5.59 ± 4.86)% to (8.79 ± 6.02)% after three cycles,and reached (15.81 ± 10.73)% after six cycles of treatment. The other 5 patients who had no lipid peak before chemotherapy showed lipid peak during treatment. There were 4 cases (4/30) without showing lipid peak during the whole chemotherapy course. Conclusion:Hepatic fat content increased during chemotherapy in breast cancer patients. 1HMRS provides a noninvasive tool to monitor hepatic fat content change and detect chemotherapy related liver toxicity.关键词
磁共振波谱学；肝脏脂肪变性；乳腺癌/化疗Key words
maganetic resonance spectroscopy/hepatic steatosis/cancer of mammary gland/chemotherapy分类
医药卫生引用本文复制引用
徐化凤,齐静,秦斌,徐青..1H-MRS动态监测乳腺癌患者化疗后的肝脏脂肪含量的变化[J].南京医科大学学报（自然科学版）,2011,31(8):1169-1172,4.基金项目
国家自然科学基金资助(30700191)；江苏省自然科学基金资助(BK2006578) （30700191）
