南京医科大学学报（自然科学版）2011，Vol.31Issue(8)：1192-1195,1211,5.
白藜芦醇对胃腺癌细胞株增殖和凋亡的影响
The effects of Resveratrol on the proliferation and apoptosis of gastric adenocarcinoma cell lines
摘要
Abstract
Objective:To investigate the effects of Resveratrol on the proliferation and apoptosis of gastric cancer cell lines. Methods:Gastric cancer cell lines BGC823 and SGC7901 were treated with Resveratrol (0 ～150 μmol/L) for different time (24 ～ 72 h). The proliferation,apoptosis and survivin protein expression of gastric cancer cells were detected by the CCK-8 kit,flow cytometry and Western blot,respectively. Results:Resveratrol inhibited the proliferation of BGC823 and SGC7901 in dose-and timedependant model. The early and late apoptosis rates of BGC823 and SGC7901 were highly increased by treatment of 150 μmol/L Resveratrol for 72 h,while Survivin protein expression decreased significantly (all P < 0.05). Conclusion:Resveratrol inhibits the proliferation and induces the apoptosis of BGC823 and SGC7901, in which the down-regulation of survivin protein may be involved.关键词
白藜芦醇；胃癌细胞；凋亡；survivin蛋白Key words
Resveratrol/gastric cancer cell lines/apoptosis/survivin protein分类
医药卫生引用本文复制引用
李运红,陈敏,邹晓平,于成功,吕瑛,张晓琦,徐肇敏..白藜芦醇对胃腺癌细胞株增殖和凋亡的影响[J].南京医科大学学报（自然科学版）,2011,31(8):1192-1195,1211,5.基金项目
江苏省自然科学基金资助(BK2007005) （BK2007005）
