南京医科大学学报（自然科学版）2011，Vol.31Issue(8)：1196-1199,1207,5.
HER4在乳腺癌中的表达及临床意义
Expression and clinical significance of HER4 in breast carcinoma
张玲 1刘标 2俞士尤 3孟优 3周俊东 1吴锦昌1
作者信息
- 1. 南京医科大学附属苏州医院肿瘤放疗科，江苏苏州215001
- 2. 南京医科大学附属苏州医院病理科，江苏苏州215001
- 3. 南京医科大学附属苏州医院肿瘤外科，江苏苏州215001
- 折叠
摘要
Abstract
Objective:To investigate the relationship between expression of HER4,HER2,ER and PR and evaluate them on the clinical prognosis of human breast carcinoma. Methods:The expressions of HER4,HER2,ER and PR were studied in 105 cases with breast carcinoma by using SP imraunohistochemistry. The endpoint of follow-up was disease free survival (DFS). Results: HER2, HER4,ER and PR expression were detected in 105 cases with positive rates of 37.14%,20.00%,40.00%,28.27%,respectively. The expression intensity of HER2,HER4,ER and PR in breast carcinoma had no significant correlation with the age,lymph node metastasis,pathological types,TNM stage,chemotherapy of the patients (P > 0.05). HER4 can be a co-activator of ER and PR expression (P = 0.030,P = 0.028). Compared with those with HER4-positive profiles,patients with HER4-negative profiles had significantly lower DFS(P = 0.039). Patients with HER4-positive and HER2-negative expression profiles had significantly longer DFS (P = 0.000) than other groups. Conclusion:HER4 expression is an independent predictor of breast cancer. Patients with HER4positive have longer DFS, and HER4 can be a co-activator of ER and PR.关键词
HER4；HER2；乳腺癌；免疫组织化学Key words
HER4/HER2/breast carcinoma/immunohistochemistry分类
医药卫生引用本文复制引用
张玲,刘标,俞士尤,孟优,周俊东,吴锦昌..HER4在乳腺癌中的表达及临床意义[J].南京医科大学学报（自然科学版）,2011,31(8):1196-1199,1207,5.
