南京医科大学学报（自然科学版）2011，Vol.31Issue(8)：1204-1207,4.
TGFB1基因T869C位点多态性与类风湿性关节炎易感性的Meta分析
The association study between the TGFB1 T869C polymorphism and RA susceptibility:a meta-analysis
摘要
Abstract
Objective:To explore the association between the TGFB1 T869C polymorphism and rheumatoid arthritis (RA) susceptibility. Methods:PubMed and CMB databases were searched to get the case-control studies on the association between the T869C polymorphism and RA susceptibility. Further,OR with the association was obtained from the meta-analysis. Then heterogeneity,stratified analysis,and publication bias test were conducted in the study. Results:A total of seven eligible studies with 1 122 RA cases and 1 132 controls were included in this meta-analysis. No significant association was found in any genetic model between the T869C polymorphism and RA risk using fixed model or random model. However,in the subgroup of races,we found that the T869C polymorphism was significantly associated with risk of AR in codominant and dominant model among Asians. Conclusion:The TGFB1 T869C polymorphism may contribute to RA risk among Asians.关键词
TGFB1；类风湿性关节炎；Meta分析Key words
TGFB1/rheumatoid arthritis/meta-analysis分类
医药卫生引用本文复制引用
李新华,任永信..TGFB1基因T869C位点多态性与类风湿性关节炎易感性的Meta分析[J].南京医科大学学报（自然科学版）,2011,31(8):1204-1207,4.基金项目
江苏省卫生厅兴卫工程医学重点人才项目(RC2007060) （RC2007060）
