南京医科大学学报（自然科学版）2011，Vol.31Issue(6)：843-846,4.
体外循环中肺动脉灌注和间断肺通气的肺保护作用
Protective effects of pulmonary artery perfusion and intermittent ventilation on lung during cardiopulmonary bypass
摘要
Abstract
Objective:To explore the protective effects of comprehensive measures,including pulmonary artery perfusion with 4℃ oxygenated blood and intermittent ventilation on lung during CPB. Methods:Thirty patients with rheumatic heart disease (RHD) or congenital heart defect (CHD) were divided into two groups with random dumber table: protective group (n =15), given simultaneously intermittent ventilation and pulmonary artery perfusion with 4℃ oxygenated blood on lung during CPB; control group (n =15) , performed using routine approaches. Mechanical ventilation time was recorded, the lung oxygenate index (OI), respiratory index (RI), airway resistance(Raw) and lung static compliance (Cstat) were detected at the beginning, ending, 1 h and 6 h after CPB termination, respectively. Results:The time of mechanical ventilation was significantly shorter in protective group than in the control group. The OI and Cstat of protective group at 1 h and 6 h after CPB termination was significantly better than that of the control group (P＜0.05, P＜0.01, respectively); the Raw and RI of protective group was significantly lower than that of control group at 1 h and 6 h (P＜0.05, P＜0.01, respectively). Conclusion Comprehensive measures, pulmonary artery perfusion with 4℃ oxygenated blood and intermittent ventilation, has protective effects on lung injury during CPB.关键词
体外循环/肺保护/肺动脉灌注/间断肺通气Key words
cardiopulmonary bypass/ lung protection/ pulmonary artery perfusion/ intermittent ventilation分类
医药卫生引用本文复制引用
任王胜,吴延虎,王晓伟,刘翔,梁永年,朱锦富..体外循环中肺动脉灌注和间断肺通气的肺保护作用[J].南京医科大学学报（自然科学版）,2011,31(6):843-846,4.基金项目
江苏省卫生厅医学科技发展基金(H200603) （H200603）
