南京医科大学学报（自然科学版）2011，Vol.31Issue(6)：872-876,5.
食管鳞状细胞癌中CD24的表达及其临床意义
The expression and clinical significance of CD24 in human esophageal squamous cell carcinoma
詹必成 1陈亮 1朱全 1张石江1
作者信息
- 1. 南京医科大学第一附属医院胸心外科,南京江苏,210029
- 折叠
摘要
Abstract
Objective:To investigate the expression and clinical significance of CD24 in human esophageal squamous cell carcinoma (ESCC). Methods:CD24 expression of 63 esophageal squamous cell carcinomas was analyzed by SP immunohistochemistiy,and the expression level of CD24 was calculated by the positive cells ratio. Results :CD24 expression was observed in cytomembrane, cytoblast and cytoplasm in esophageal squamous cell carcinoma tissues. The positive rates were 8O.95%(51/63) ,88.88%(56/63)and 85.71%(54/63).respectively,which were obviously higher than 55.56%(35/63),50.79%(32/63) and 0 in the normal esophageal tissues. The expression of CD24 was increasing with the deep of invasion, the increasing number of regional lymph nodes, the distant metastasis and the clinical stage of tumor. The differences among each groups were statistically significant (all P＜0.05). Conclusion;The expression of CD24 has a positive correlation with the depth of invasion, the regional lymph nodes, the distant metastasis and the TNM stage of esophageal squamous cell carcinoma (P＜0.05). The expression of CD24 may play a significant role in the development of the esophageal squamous cell carcinoma and be a new independent prognostic marker in tumor progression of this disease.关键词
CD24/食管鳞癌/预后指标Key words
CD24/ esophageal squamous cell carcinoma prognostic marker分类
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詹必成,陈亮,朱全,张石江..食管鳞状细胞癌中CD24的表达及其临床意义[J].南京医科大学学报（自然科学版）,2011,31(6):872-876,5.
