南京医科大学学报（自然科学版）2011，Vol.31Issue(6)：882-884,888,4.
抗病毒治疗在伴高滴度HBV-DNA原发性肝癌术后复发中的作用
A study of antiviral therapy in prevention of tumor recurrence after radical liver resection of hepatocellular carcinoma with high load of hepatitis B virus DNA
成峰 1吕凌 1孙倍成 1李国强 1李相成 1张峰 1王学浩1
作者信息
- 1. 南京医科大学第一附属医院肝脏移植中心,江苏南京,210029
- 折叠
摘要
Abstract
Objective:To evaluate the effects of antiviral therapy in prevention of tumor recurrence after curative treatment for patients with hepatocellular carcinoma (HCC). Methods; Between Aug 2003 and Aug 2008, 93 patients undergoing radical liver resection for HCC were enrolled in the retrospective analysis. Patients were assigned to two groups; 43 cases of patients (serum HBV-DNA ≥ l.0×l05 copies/ml) without lamivudine antiviral therapy after operation and 50 cases of patients (serum HBV-DNA ≥ l.0×l05 copies/ml) received lamivudine (100 mg/d) antiviral therapy after operation. The Kaplan-Meier method was used to calculate the tumor-free survival rates, Log-rank test was performed to evaluate the difference between two groups. Results:All patients were fol-lowed-up, the overall recurrence rate and mortality were 78.49%(73 cases ) and 69.89%(65 cases). The 1,3,5-year recurrence rate was 76.74%, 44.19%, 13.95% in radical liver resection group without antiviral therapy and 88.25%, 69.78%, 28.73% in radical liver resection group received lamividine antiviral therapy(P = 0.014 3). Conclusion; The study suggested that antiviral therapy after radical liver resection in patients with HCC can reduce the tumor recurrence and those patients with HBV-DNA≥1.0×105 copies/ml should received an antiviral therapy as early as possible after extirpation of the primary tumor.关键词
肝细胞肝癌/抗病毒治疗/复发Key words
hepatocellular carcinoma/ antiviral therapy/ recurrence分类
医药卫生引用本文复制引用
成峰,吕凌,孙倍成,李国强,李相成,张峰,王学浩..抗病毒治疗在伴高滴度HBV-DNA原发性肝癌术后复发中的作用[J].南京医科大学学报（自然科学版）,2011,31(6):882-884,888,4.
