天津中医药2011，Vol.28Issue(5)：418-420,3.
脑康通泰分散片的制备及溶出度测定
Determination of preparation and dissolution with Naokangtongtai dispersible tablet
摘要
Abstract
[Objective] To prepare Naokangtongtai dispersible tablets and establish the dissolution method. To compare with the dissolution of other common products. [Methods] The formulation of the tablets was optimized through the indices: slope of repose, hardness, disintegration time and corpuscular liquidity. Dissolution was determined by the solvent according to the method in Chinese Pharma-copoeia(2010, Appendix Ⅱ) with 900 mL water as the solvent at a rotation speed of 100 r/min. And the detection wavelength was 270 nm. [Results] The proportion of each adjuvant in the optimal formulation consisted of 20% microcrystalline cellulose and 24% brushite as a filler, and 10% crospovidone mixed with 2% silicon dioxide as disintegrating agent, 1% magnesium stearate as lubricants. The dispersible tablets could disintegrate completely within 3 minutes and its dissolution rate could reach beyond 75% in 30 min. [Conclusion] The preparative method of Naokangtongtai dispersible tablets by wet granulation is simple. The method is accurate and suitable for the dissolution determination of Naokangtongtai dispersible tables.关键词
脑康通泰分散片/制备工艺/溶出度Key words
Naokangtongtai dispersible tablets preparation technology/ dissolution分类
医药卫生引用本文复制引用
王维,李洪起,邹俊忠,任晓文..脑康通泰分散片的制备及溶出度测定[J].天津中医药,2011,28(5):418-420,3.基金项目
国家重点基础研究发展计划项目(2010CB735602). （2010CB735602）
